P MRS of resting muscle at 7T: differences in the alkaline pH compartment between different muscles and sedentary and elite trained athletes
نویسندگان
چکیده
H. E. Kan, J. van Oorschot, B. H. Wokke, M. J. Versluis, N. B. Smith, A. G. Webb, and J. A. Jeneson C.J. Gorter Center, department of radiology, Leiden University Medical Center, Leiden, Netherlands, Biomedical NMR Laboratory, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, Department of neurology, Leiden University Medical Center, Leiden, Netherlands
منابع مشابه
31P MR Spectroscopy and Computational Modeling Identify a Direct Relation between Pi Content of an Alkaline Compartment in Resting Muscle and Phosphocreatine Resynthesis Kinetics in Active Muscle in Humans
The assessment of mitochondrial properties in skeletal muscle is important in clinical research, for instance in the study of diabetes. The gold standard to measure mitochondrial capacity non-invasively is the phosphocreatine (PCr) recovery rate after exercise, measured by (31)P Magnetic Resonance spectroscopy ((31)P MRS). Here, we sought to expand the evidence base for an alternative method to...
متن کاملCSI and MRS at 7T detect an alkaline pH compartment in resting human soleus muscle
Introduction. Non-invasive fiber-type profiling of human skeletal muscles has been a longtime objective in musculoskeletal MR research. Past MR investigations have typically looked for differential metabolic and pH changes (‘split Pi peak’) in contracting muscles (1,2). There is, however, some evidence that intracellular pH may also be a sensitive biomarker of muscle fiber type composition in r...
متن کاملSkeletal muscle alkaline Pi pool is decreased in overweight-to-obese sedentary subjects and relates to mitochondrial capacity and phosphodiester content
Defects in skeletal muscle energy metabolism are indicative of systemic disorders such as obesity or type 2 diabetes. Phosphorus magnetic resonance spectroscopy ((31)P-MRS), in particularly dynamic (31)P-MRS, provides a powerful tool for the non-invasive investigation of muscular oxidative metabolism. The increase in spectral and temporal resolution of (31)P-MRS at ultra high fields (i.e., 7T) ...
متن کاملDifferent metabolic responses during incremental exercise assessed by localized 31P MRS in sprint and endurance athletes and untrained individuals.
Until recently, assessment of muscle metabolism was only possible by invasive sampling. 31P magnetic resonance spectroscopy (31P MRS) offers a way to study muscle metabolism non-invasively. The aim of the present study was to use spatially-resolved 31P MRS to assess the metabolism of the quadriceps muscle in sprint-trained, endurance-trained and untrained individuals during exercise and recover...
متن کاملCardiac Troponin T Response during High-Intensity Competition and its Correlation with the Corrected QT Interval among the Trained Athletes
Introduction: It is highly crucial to develop novel strategies in order to further enhance the monitoring of sudden cardiac arrest in athletes and establish standard medical care procedures to control monitoring and treatment costs. Therefore, this study aimed to investigate the effects of a high-intensity competition on cardiac troponin T (cTnT) and its correlation with the corrected QT interv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009